Hydrolyzed Collagen: Benefits, Types & Recommended Dosage

For the skin

Collagen is THE main component of our skin, at around 80%. Together with elastin, collagen forms the supporting corset that gives our skin and the underlying connective tissue firmness and elasticity. In addition, collagen also has plumping effects due to its water-binding properties.

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From the age of around 25, the body’s own collagen production begins to decline by about 1.5% per year, leading to ever more visible changes. From this age onwards, the targeted intake of hydrolysed collagen is therefore worthwhile and is an ideal strategy to counteract natural skin ageing and to nurture the beauty of the sensitive outer barrier from within.

Hydrolysed collagen enters the small intestine when taken orally, where it is absorbed into the bloodstream in the form of small collagen peptides and free amino acids. It thus has a dual effect.

• Firstly, the free amino acids serve as building blocks for the formation of collagen and elastin fibres.
• Secondly, the collagen peptides stimulate the formation of new collagen, elastin and hyaluronic acid.

Building muscle

While in the beauty world, nothing beats collagen hydrolysate, peptide powder is still considered a secret tip among athletes. Although there are isolated studies on muscle growth for collagen hydrolysate that demonstrate a benefit for fat-free mass and strength, there are certainly more suitable sources of protein specifically for muscle growth. Nonetheless, collagen hydrolysate is a good suggestion for athletes for the regeneration and strengthening of their musculoskeletal system. More about this in the following point.

Muscles, cartilage & joints

Collagen is always found where the tissue has to withstand high tensile stress – whether in muscles, ligaments, tendons or cartilage. These structures are subject to enormous forces, particularly when under sporting stress. The fact that the targeted use of collagen hydrolysate not only strengthens the collagen-dependent structures of the musculoskeletal system, but in certain cases can be useful even in the case of already existing problems, has been shown, among other things, by a randomised placebo-controlled interventional study. In this study, 147 athletes with arthritis-related joint pain received either collagen hydrolysate (10 g daily) for 24 weeks or a placebo. After the end of the study, the results analysis showed that there was a partially significant reduction in pain in the collagen hydrolysate group.

The branded raw material NATICOL® has undergone a variety of clinical studies with a beauty focus, which were conducted in collaboration with research institutes as well as specialist clinics and hospitals.

A double-blind, randomised and placebo-controlled study published in investigated the anti-ageing potential of 5 g Naticol® fish collagen peptides in 60 healthy female subjects aged 35 to 70 years. The test zones included the facial skin, abdominal skin and forearm skin.

After 8 weeks of regular intake of 5 g Naticol®, significant improvements in skin firmness on the abdomen, face and forearms as well as a reduction in wrinkles were found. The results also suggested that Naticol® could have a preventive effect against dehydration in cold weather conditions.

Would you like to dive even further into the subject and read more in studies on collagen or collagen hydrolysate? Under the item "In-depth studies", you will find some of the studies that we consulted in our various collagen research.

Conclusion: Collagen is not only a beauty booster for our skin, it also benefits our muscles, cartilage and tendons. If you want to get the most out of the various benefits of structural protein, collagen hydrolysate from fish is to be particularly recommended. This is not only considered easy to digest and absorb, it also mainly supplies the highly sought-after type I collagen in a particularly bioavailable peptide form.

Further reading:

Asserin, J. et al. . The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo-controlled clinical trials. J Cosmet Dermatol. Dec;14(4):291-301. doi: 10./jocd.. Epub Sep 12. https://pubmed.ncbi.nlm.nih.gov//

Choi, F.D. . Oral Collagen Supplementation: A Systematic Review of Dermatological Applications. J Drugs Dermatol. Jan 1;18(1):9-16. https://pubmed.ncbi.nlm.nih.gov//

De Miranda, R.B. et. al. . Effects of hydrolyzed collagen supplementation on skin aging: a systematic review and meta-analysis. Int J Dermatol. Dec;60(12):-. doi: 10./ijd.. Epub Mar 20. https://pubmed.ncbi.nlm.nih.gov//

Evans, M. et al. . A randomized, triple-blind, placebo-controlled, parallel study to evaluate the efficacy of a freshwater marine collagen on skin wrinkles and elasticity. Journal of Cosmetic Dermatology. 20(3):825–834. https://pubmed.ncbi.nlm.nih.gov//

Sibilla, S. et al. . An Overview of the Beneficial Effects of Hydrolysed Collagen as a Nutraceutical on Skin Properties: Scientific Background and Clinical Studies. The Open Nutraceuticals Journal. 8(1). https://pubmed.ncbi.nlm.nih.gov//

De Almagro, M. C. . The Use of Collagen Hydrolysates and Native Collagen in Osteoarthritis. AJBSR. 7(6):530–532. https://pubmed.ncbi.nlm.nih.gov//

Hong, H. et al. . Preparation of low-molecular-weight, collagen hydrolysates (peptides): Current progress, challenges, and future perspectives. Food Chemistry. 301:. https://pubmed.ncbi.nlm.nih.gov//

Campos Mbg, P. M. . An Oral Supplementation Based on Hydrolyzed Collagen and Vitamins Improves Skin Elasticity and Dermis Echogenicity: A Clinical Placebo-Controlled Study. Clin Pharmacol Biopharm. 04(03). https://www.researchgate.net/publication/_An_Oral_Supplementation_Based_on_Hydrolyzed_Collagen_and_Vitamins_Improves_Skin_Elasticity_and_Dermis_Echogenicity_A_Clinical_Placebo-Controlled_Study

Castillo-Briceño, P. et al. . A role for specific collagen motifs during wound healing and inflammatory response of fibroblasts in the teleost fish gilthead seabream. Mol Immunol. 48(6–7):826–834. https://pubmed.ncbi.nlm.nih.gov//

Geahchan, S. et al. . Marine Collagen: A Promising Biomaterial for Wound Healing, Skin Anti-Aging, and Bone Regeneration. Mar Drugs. 20(1):61. https://pubmed.ncbi.nlm.nih.gov//

Duteil, L. et al. . SPECIFIC NATURAL BIOACTIVE TYPE 1 COLLAGEN PEPTIDES ORAL INTAKE REVERSE SKIN AGING SIGNS IN MATURE WOMEN. J Aging Res & Lifestyle. :1–9. https://www.jarlife.net/-specific-natural-bioactive-type-1-collagen-peptides-oral-intake-reverse-skin-aging-signs-in-mature-women.html

Lugo, J. P. et al. . Efficacy and tolerability of an undenatured type II collagen supplement in modulating knee osteoarthritis symptoms: A multicenter randomized, double-blind, placebo-controlled study. Nutr J. Jan 29;15:14.  doi: 10./s-016--8. https://pubmed.ncbi.nlm.nih.gov//

Zdzieblik, D. et. al. . Collagen peptide supplementation in combination with resistance training improves body composition and increases muscle strength in elderly sarcopenic men: a randomised controlled trial. Br J Nutr. Oct 28;114(8):-45. doi: 10./S. Epub Sep 10. https://pubmed.ncbi.nlm.nih.gov//

Mohammed A., He S. . A Double-Blind, Randomized, Placebo-Controlled Trial to Evaluate the Efficacy of a Hydrolyzed Chicken Collagen Type II Supplement in Alleviating Joint Discomfort. Nutrients. Jul 18;13(7):. doi: 10./nu. https://pubmed.ncbi.nlm.nih.gov//

 Li W, Sun K, Ji Y, Wu Z, Wang W, Dai Z, Wu G. Glycine Regulates Expression and Distribution of Claudin-7 and ZO-3 Proteins in Intestinal Porcine Epithelial Cells. J Nutr. May;146(5):964-9. doi: 10./jn.115.. Epub Mar 30. PMID: . https://pubmed.ncbi.nlm.nih.gov//

Howard A, Tahir I, Javed S, Waring SM, Ford D, Hirst BH. Glycine transporter GLYT1 is essential for glycine-mediated protection of human intestinal epithelial cells against oxidative damage. J Physiol. Mar 15;588(Pt 6):995-. doi: 10./jphysiol... Epub Feb 1. PMID: ; PMCID: PMC https://pubmed.ncbi.nlm.nih.gov//

Wu G, Bazer FW, Burghardt RC, Johnson GA, Kim SW, Knabe DA, Li P, Li X, McKnight JR, Satterfield MC, Spencer TE. Proline and hydroxyproline metabolism: implications for animal and human nutrition. Amino Acids. Apr;40(4):-63. doi: 10./s-010--z. Epub Aug 10. PMID: ; PMCID: PMC. https://pmc.ncbi.nlm.nih.gov/articles/PMC/

Zhu S, Huang M, Feng G, Miao Y, Wu H, Zeng M, Lo YM. Gelatin versus its two major degradation products, prolyl-hydroxyproline and glycine, as supportive therapy in experimental colitis in mice. Food Sci Nutr. Apr 16;6(4):-. doi: 10./fsn3.639. PMID: ; PMCID: PMC. https://pubmed.ncbi.nlm.nih.gov//

Asserin, Jérome et al. . The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo-controlled clinical trials. Journal of cosmetic dermatology vol. 14,4 (): 291-301. doi:10./jocd. https://pubmed.ncbi.nlm.nih.gov//

Damodarasamy, Mamatha et al. . Hyaluronan enhances wound repair and increases collagen III in aged dermal wounds. Wound repair and regeneration: official publication of the Wound Healing Society [and] the European Tissue Repair Society vol. 22,4 (): 521-6. doi:10./wrr. https://pubmed.ncbi.nlm.nih.gov//

Clark, K.L., et al. . 24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain. Curr Med Res Opin. May;24(5):-96. doi: 10./×. https://pubmed.ncbi.nlm.nih.gov//

Dressler, P. et al. . Improvement of Functional Ankle Properties Following Supplementation with Specific Collagen Peptides in Athletes with Chronic Ankle Instability. J Sports Sci Med. Jun; 17(2): 298–304. https://pubmed.ncbi.nlm.nih.gov//

Oertzen-Hagemann, V., et al. . Effects of 12 Weeks of Hypertrophy Resistance Exercise Training Combined with Collagen Peptide Supplementation on the Skeletal Muscle Proteome in Recreationally Active Men. Nutrients, 11(5). https://pubmed.ncbi.nlm.nih.gov//

Kirmse, M., et al. . Prolonged Collagen Peptide Supplementation and Resistance Exercise Training Affects Body Composition in Recreationally Active Men. Nutrients, 11(5). https://pubmed.ncbi.nlm.nih.gov//

Lebensmittelchemische Gesellschaft. : https://www.gdch.de/fileadmin/downloads/Netzwerk_und_Strukturen/Fachgruppen/Lebensmittelchemiker/Arbeitsgruppen/kosmetik/db_proteine1.pdf, Zugriff: 1.10.

In recent years, dietary supplements containing collagen have attracted many people seeking to improve joint comfort or enhance their skin's radiance. And if you're reading this, you're probably one of them!

As a structural protein of body tissues, collagen contributes to the elasticity and suppleness of the epidermis, as well as the strength and flexibility of ligaments, cartilage, and tendons.

But when it comes to choosing a collagen supplement, a question arises: hydrolyzed marine collagen or native marine collagen? Not much is said about the difference between hydrolyzed collagen and its native (or denatured) version, yet it's not a trivial matter!

Want more information on hydrolyzed fish collagen manufacturers? Feel free to contact us.

What are the specific characteristics of hydrolyzed marine collagen VS native collagen? What are the conclusions of recent scientific studies? What criteria should you check before making your choice?

☝️ We answer the question that many of our customers ask us (and we've delved deeply into the topic too!)

A preliminary reminder: what is collagen?

Collagen: an essential role in the body

Collagen is the major protein in the human body (and throughout the animal kingdom).

Like a "binder", it provides mechanical resistance to stretching and helps maintain the flexibility and elasticity of body tissues, from cartilage to skin!

Collagen is primarily produced by fibroblast cells, as well as chondrocytes and osteoblasts, until around the age of 25. After that, the amount of collagen in the body gradually decreases (and permanently).

This decrease is correlated with the natural aging of the skin (and our first wrinkles), reduced joint resistance, and a longer recovery time after injury. Certainly, aging isn't very appealing!

In the food, pharmaceutical, and dietary supplement industries, it can be extracted from mammals (beef, pork, chicken) or fish and shellfish.

☝️ Note: We will only discuss marine-sourced collagen here, as we believe it is the best collagen, in line with our values: quality, high bioavailability, traceability, and sustainability.

We recommend

Hydrolyzed Marine Collagen Powder

Hydrolyzed Marine Collagen powder of types I & III.

• ✅ Fine powder easy to dissolve
• ✅ Available in 3 flavors
• ✅ 1 month supply
• ✅ Made in France