What Is 4-Trifluoromethoxyphenylboronic Acid CAS 139301-27-2? Properties, Uses, and Buying Considerations

4-Trifluoromethoxyphenylboronic acid, also known as 4-(trifluoromethoxy)phenylboronic acid, is an aryl boronic acid used primarily as a synthetic building block in cross-coupling chemistry. It is identified by CAS 139301-27-2 and contains both a boronic acid group and a para-trifluoromethoxy substituent on an aromatic ring. I position this material for research, medicinal chemistry, pharmaceutical intermediate development, and other applications that require a fluorinated aryl partner for carbon–carbon bond formation.

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Its commonly listed molecular formula is C₇H₆BF₃O₃, with a molecular weight of approximately 205.93 g/mol. The molecule contains 3 fluorine atoms, while the boronic acid group provides the reactive site used in many Suzuki–Miyaura coupling reactions. As Maison Chemical, I recommend confirming the current specification, appearance, assay, residual solvents, and packaging requirements before placing a commercial order.

Identity and Core Properties

Chemical identity

4-Trifluoromethoxyphenylboronic acid is an aromatic organoboron compound. The boronic acid functionality is attached directly to a phenyl ring, and the trifluoromethoxy group is located at the para position relative to the boronic acid group. This substitution pattern can be important when researchers are designing molecules that require a defined electronic and steric arrangement.

The compound is generally handled as a solid chemical intermediate. Exact color, particle form, water content, and stability can vary according to manufacturing process, storage conditions, and packaging. For that reason, I advise buyers to treat catalog descriptions as preliminary information and use the supplier’s current certificate of analysis as the controlling document for a specific batch.

Useful specification points

These values help procurement and laboratory teams distinguish the material from related compounds such as 4-fluorophenylboronic acid, 4-trifluoromethylphenylboronic acid, or other positional isomers. They should not replace analytical confirmation. When identity is critical, I recommend reviewing appropriate analytical data such as NMR, mass spectrometry, chromatographic purity, and water content, depending on the project stage.

Core Functions in Organic Synthesis

The principal function of this compound is to serve as a boronic acid coupling partner. Under suitable reaction conditions, the arylboronic acid can participate in Suzuki–Miyaura coupling with an appropriate aryl or vinyl halide or related electrophile. This allows chemists to introduce a 4-trifluoromethoxyphenyl fragment into a more complex molecular structure.

The trifluoromethoxy group is also a design feature rather than a passive label. Fluorinated substituents are often evaluated in medicinal and agrochemical research because they can influence lipophilicity, metabolic behavior, electronic properties, and molecular conformation. The actual effect depends on the complete target structure, so I recommend making decisions from project-specific data rather than assuming that one substituent will deliver the same result in every molecule.

Application Scenarios

Medicinal chemistry and pharmaceutical research

Research teams may use 4-Trifluoromethoxyphenylboronic acid to prepare substituted biaryl compounds, heteroaryl–aryl systems, and other screening molecules. It can be useful during analog generation when a project is comparing different fluorinated or electron-modifying substituents. In these settings, buyers usually value consistent identity, reliable assay, suitable pack sizes, and documentation that supports internal compound registration.

Agrochemical and specialty chemical development

Fluorinated aromatic fragments are also explored in agrochemical and performance-oriented molecule development. The compound may be selected as an intermediate for laboratory synthesis rather than as a final-use ingredient. Since each route has different catalyst, solvent, purification, and scale requirements, the suitability of this boronic acid should be confirmed through route-specific experiments.

Process development and custom synthesis

At a later development stage, the focus often shifts from milligram availability to reproducible supply, controlled packaging, and predictable lead times. A material that performs well in a small reaction may still require additional evaluation before use at larger scale. I encourage process teams to review impurity profiles, lot-to-lot consistency, storage duration, and transport conditions before approving a long-term supply plan.

Material Options and Specification Considerations

Commercial availability may differ by purity grade, package size, and documentation level. A research buyer may request a small quantity for route screening, while a process-development customer may need a larger quantity with a defined assay range and additional analytical information. If the intended application is regulated or quality-sensitive, the buyer should clearly state the documentation requirements before quotation.

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Purity should be discussed carefully because “high purity” is not a universal specification. For example, a buyer may request a target such as 98% or higher by a stated analytical method, but the acceptable level depends on the reaction, impurity sensitivity, and downstream purification strategy. I do not recommend treating an assay number alone as proof of suitability; water content, residual solvents, inorganic residues, and related substances may also affect performance.

How Buyers Should Select a Supplier

Confirm identity and analytical documentation

Start by matching the product name, CAS number, molecular formula, and molecular weight. Then request a batch-specific certificate of analysis and ask which analytical methods are used for assay and identity. If the material will enter a critical synthesis route, buyers should also discuss whether supporting spectra or additional testing can be provided.

Review packaging and storage

Boronic acids can be sensitive to moisture and prolonged exposure to unsuitable storage conditions, although the practical stability profile depends on the exact material and packaging system. I recommend asking for the supplier’s storage guidance, recommended container type, retest or review information where applicable, and shipping arrangement. The receiving site should also have procedures for inspection, quarantine, and controlled release of incoming chemicals.

Evaluate supply continuity

Price is only one part of the purchasing decision. Buyers should compare minimum order quantity, sample availability, production schedule, export documentation, delivery terms, and the supplier’s ability to support repeat orders. A lower initial price may not be advantageous if the specification changes between batches or if replenishment requires an uncertain lead time.

Handling and Technical Cautions

As with other laboratory and industrial organic intermediates, this compound should be handled according to its current safety data sheet and the risk assessment of the receiving facility. Personnel should use appropriate protective equipment, avoid generating dust, and work with suitable ventilation and chemical hygiene controls. I recommend that customers verify the latest hazard classification because regulatory requirements can vary by jurisdiction and may depend on the supplied form.

Reaction performance can be influenced by base, solvent, catalyst, temperature, substrate type, and water content. A successful literature reaction is not a guaranteed operating procedure for every substrate or scale. Buyers should perform controlled feasibility work and confirm conversion, selectivity, isolation behavior, and impurity formation before making process commitments.

Maison Chemical Supplier Support

At Maison Chemical, I support B2B customers by clarifying product identity, intended use, quantity requirements, packaging expectations, and documentation needs before quotation. Our discussion can cover research quantities, development-stage supply, export coordination, and repeat-order planning, subject to product availability and agreed specifications. This approach helps align the commercial offer with the buyer’s actual technical requirements.

For an efficient inquiry, please provide the requested quantity, destination country, target purity, preferred packaging, application stage, and any required documents. If you are comparing this compound with another aryl boronic acid, sharing the target reaction or structural requirement can also help us identify the relevant specification points. We can then confirm current availability, pricing, lead time, and applicable shipping details without making assumptions about your process.

Key Takeaways

• 4-Trifluoromethoxyphenylboronic acid is an aryl boronic acid identified by CAS 139301-27-2.
• Its commonly listed molecular formula is C₇H₆BF₃O₃, with a molecular weight of approximately 205.93 g/mol.
• Its primary role is as a fluorinated aryl building block, especially for Suzuki–Miyaura coupling development.
• Buyers should verify assay, identity, water content, related substances, packaging, storage, and documentation requirements.
• Supplier selection should consider technical suitability and supply continuity, not price alone.

Conclusion and Next Steps

In direct answer to the question, 4-Trifluoromethoxyphenylboronic acid CAS 139301-27-2 is a fluorinated aromatic boronic acid used to introduce a 4-trifluoromethoxyphenyl group into more complex molecules. Its value comes from the combination of a reactive boronic acid coupling site and a defined fluorinated substituent. The most appropriate applications are synthetic research, medicinal chemistry, agrochemical exploration, and process-development routes where this fragment matches the target design.

Before buying, I recommend confirming the identity, analytical specification, required quantity, packaging, storage guidance, and delivery schedule. Contact Maison Chemical with your target quantity and documentation requirements so we can review the appropriate supply option for your project.

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