What Is 2-(Thiophen-2-yl)phenol CAS 106584-13-8? Properties, Uses, and Buying Information

2-(Thiophen-2-yl)phenol, identified by CAS No. 106584-13-8, is an aromatic sulfur-containing phenolic compound used primarily as a research chemical, synthetic building block, and potential intermediate in advanced organic chemistry. Its structure combines a phenol ring with a thiophen-2-yl substituent, giving the molecule both a hydroxyl group and a sulfur-containing heteroaromatic ring. At Maison Chemical, we treat this material as a specification-controlled specialty chemical rather than a commodity product, so buyers should confirm identity, assay, impurity limits, packaging, and documentation before placing an order.

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The molecular formula generally associated with this structure is C₁₀H₈OS, with a calculated molecular weight of approximately 176.23 g/mol. Because physical appearance, purity, residual solvents, and analytical results can vary by manufacturing route and batch, I recommend using the current product specification and certificate of analysis as the controlling documents. Buyers should not rely on a database entry alone when the material will be used in a regulated, pharmaceutical, or scale-up process.

Identity and Molecular Structure

What the name describes

The name “2-(thiophen-2-yl)phenol” describes the relative positions of the two aromatic components. A phenol ring contains the hydroxyl group, while the thiophen-2-yl group is attached through the second carbon position of a thiophene ring. This arrangement creates a biaryl-type structure containing one oxygen atom, one sulfur atom, and two aromatic ring systems.

The phenolic hydroxyl group can participate in hydrogen bonding and can influence the compound’s polarity and chemical reactivity. The thiophene ring contributes sulfur-containing heteroaromatic character, which is relevant when chemists evaluate electronic properties or plan further functionalization. These structural features explain why the compound may be considered in medicinal chemistry, materials research, and intermediate development, although the suitability of the material must be demonstrated for each intended reaction or formulation.

Core Properties and What Buyers Should Verify

Known identity data

Publicly available records may not provide a complete, consistent set of physical-property values for every commercial batch. For this reason, I do not recommend presenting a melting point, boiling point, color, solubility profile, or storage period as universal unless it has been verified for the exact batch or specification being purchased. A professional inquiry should request appearance, assay method, chromatographic purity, water content where relevant, residual solvents, and recommended storage conditions.

In laboratory planning, a buyer may begin with a small evaluation quantity such as 1 g or 10 g before moving to a larger manufacturing quantity. These quantities are procurement examples, not claims about standard stock availability. The appropriate amount depends on the reaction screen, analytical requirements, process development stage, and expected yield.

Functions and Potential Applications

Use as a synthetic building block

The most practical role of 2-(thiophen-2-yl)phenol is as an aromatic building block for organic synthesis. Its phenolic hydroxyl group may be involved in derivatization, protection, ether formation, ester formation, or other transformations selected by the chemist. The thiophene ring may also serve as a functional aromatic component in further coupling or substitution chemistry, subject to the reaction design and catalyst system.

These possibilities do not mean that every reaction will provide the same conversion, selectivity, or yield. The actual outcome depends on reagent quality, solvent, temperature, catalyst, reaction time, work-up, and purification. I recommend performing a controlled laboratory evaluation before committing to a production-scale purchase.

Pharmaceutical and medicinal chemistry research

Heteroaromatic phenols are often considered during the design and preparation of compound libraries, analogues, and exploratory research molecules. In this context, 2-(thiophen-2-yl)phenol may be selected as a starting fragment or intermediate for preparing more complex structures. However, the compound itself should not be described as an approved pharmaceutical ingredient, active drug, or proven therapeutic agent without specific regulatory and clinical evidence.

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Materials and specialty chemistry research

The combination of a phenolic group and a thiophene ring may also make this compound relevant to exploratory work involving functional aromatic molecules, ligands, dyes, or organic materials. Such applications are development-dependent and should be supported by project-specific testing. Buyers should define whether they need research-grade material, process-development material, or a higher-control intermediate for a regulated manufacturing environment.

Material Options and Specification Levels

Choosing the appropriate commercial form

For this type of specialty chemical, “material options” usually refer to specification level, packaging, quantity, and documentation rather than fundamentally different forms of the same compound. A research project may only require identity confirmation and a stated assay, while a process-development project may require tighter impurity control and batch-to-batch consistency. A regulated application may additionally require traceability, controlled documentation, and a defined change-notification process.

• Research quantity: Suitable for initial synthesis, analytical work, and reaction screening.
• Development quantity: Appropriate when repeat experiments and process optimization are required.
• Production-support quantity: Requires discussion of forecast, batch size, quality agreement, and delivery planning.
• Custom specification: May involve agreed assay, impurity profile, packaging, and testing requirements.

Maison Chemical can review the intended use and help align the quotation with the buyer’s technical needs. We avoid treating a single generic specification as suitable for every application. Instead, I recommend confirming the target purity, acceptable impurities, analytical method, packaging format, and required quantity before the purchase order is issued.

How to Select a Reliable Supplier

Essential due diligence questions

When sourcing CAS 106584-13-8, buyers should first confirm that the supplier can provide material matching the requested chemical identity. The supplier should be able to issue a commercial specification and a batch-specific certificate of analysis when applicable. Buyers should also ask whether the quoted material is manufactured, stocked, or sourced through a third party, because this affects traceability and communication during repeat orders.

1. Confirm the CAS number, chemical name, molecular formula, and structure.
2. Request the current specification and a representative or batch-specific CoA.
3. Review assay, impurity limits, water content, residual solvents, and analytical methods.
4. Confirm packaging, labeling, storage guidance, and shipping classification.
5. Discuss MOQ, available quantity, production schedule, and repeat-order planning.
6. Verify whether technical support is available for documentation or specification questions.

Price should be evaluated together with quality risk, documentation quality, lead-time reliability, and the cost of potential requalification. A lower unit price may not be advantageous if the buyer must repeat analytical work or manage inconsistent batches. For a 1 kg scale-up or larger program, I recommend requesting a supply plan rather than evaluating only a single spot quotation.

Supplier Support from Maison Chemical

At Maison Chemical, we support B2B buyers by reviewing the application, required quantity, target specification, and delivery destination before preparing a quotation. We can discuss research, pharmaceutical-intermediate, and process-development requirements without assuming that one grade fits every project. Our role is to help buyers identify the information needed for a technically responsible purchasing decision.

For an inquiry about 2-(thiophen-2-yl)phenol CAS 106584-13-8, please include the requested quantity, target assay, packaging preference, destination country, intended use, and documentation requirements. If you have an internal specification or an existing analytical method, sharing it early can reduce clarification time. We can then review supply feasibility, available documentation, and the most suitable commercial route.

Key Takeaways

• 2-(Thiophen-2-yl)phenol CAS 106584-13-8 is a sulfur-containing aromatic phenol used mainly as a research chemical and synthetic building block.
• The commonly associated formula is C₁₀H₈OS, and the calculated molecular weight is approximately 176.23 g/mol.
• Potential uses include organic synthesis, medicinal chemistry research, and exploratory specialty-materials development.
• Physical properties and batch quality should be confirmed through current supplier documentation rather than assumed from general databases.
• Buyers should evaluate identity, assay, impurities, packaging, traceability, MOQ, lead time, and technical support before ordering.

Conclusion: Is This the Right Material for Your Project?

2-(Thiophen-2-yl)phenol CAS 106584-13-8 is a useful candidate when a project requires an aromatic molecule combining a phenolic hydroxyl group with a thiophene ring. Its value is primarily as a controllable intermediate or research building block, not as a universally validated end-use product. The correct purchasing decision depends on the planned chemistry, required purity, documentation level, quantity, and scale-up expectations.

As the next step, prepare your target specification and quantity, then request the supplier’s current technical documents and quotation. Maison Chemical can help review these requirements and assess a practical supply solution for your project. Contact our B2B team with your CAS number, intended application, quantity, and delivery requirements so we can provide a focused response.

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